High Wycombe, often referred to as Wycombe, is a market town in Buckinghamshire, England. Lying in the valley of the River Wye surro…High Wycombe, often referred to as Wycombe, is a market town in Buckinghamshire, England. Lying in the valley of the River Wye surrounded by the Chiltern Hills, it is 29 miles west-northwest of Charing Cross in London, 13 miles south-southeast of Aylesbury, 23 miles southeast of Oxford, 15 miles northeast of Reading and 8 miles north of Maidenhead.