San Francisco 49ers running back Christian McCaffrey was activated off injured reserve on Saturday and is set to make his NFL season debut on Sunday when the Niners play in Tampa Bay against the Buccaneers.

Yahoo Sports NFL analyst Nate Tice, fantasy analyst Matt Harmon, and NFL writer Charles McDonald discuss whether the return of Christian McCaffrey is enough to get the 49ers back to the Super Bowl. Hear the full conversation on “Football 301” - and subscribe on Apple Podcasts,

To help you set your fantasy football lineups and avoid starting a player on offense who won't be in the lineup, we'll post fantasy-relevant updates and analysis here as NFL teams release their official inactives lists.