RAMOSE Phase II trial finds promising results for osimertinib and ...
Dec 10, 2024 · 1. Treatment of patients with tyrosine kinase inhibitor (TKI)-naïve epidermal growth factor receptor (EGFR)-mutant non-small cell lung cancer (NSCLC) with osimertinib …
Adjuvant durvalumab therapy improves survival in limited-stage …
Nov 21, 2024 · 1. In this randomized controlled trial, adjuvant therapy with durvalumab led to improved overall and progression-free survival compared to placebo in patients with limited …
Adjunctive middle meningeal artery embolization may reduce the ...
Dec 12, 2024 · 1. In this randomized controlled trial, middle meningeal artery embolization plus surgical evacuation was associated with a lower risk of hematoma recurrence or progression …
Influenza vaccination may reduce secondary infection spread …
Dec 1, 2024 · 1. Influenza vaccination was associated with a reduced risk of secondary influenza infections among household contacts, with an estimated effectiveness of 21%. Evidence …
Radiotherapy with cetuximab or durvalumab for advanced HNSCC
Nov 18, 2024 · 1. The 2-year progression-free survival was 50.6% in the durvalumab group vs 63.7% in the cetuximab group with HR 1.33 (non-significant). 2. Regarding safety, grade 3-4 …
Landmark Trials & Summaries: The Classics in Medicine - 2 Minute …
Title Year Journal Citations Key findings; The UKPDS: Reducing the risk of diabetes-related morbidity and mortality: 1998: Lancet: 20,000: 1. For patients with type 2 diabetes mellitus, …
MRI-informed biopsy recommendation reduces overdiagnosis in …
Oct 9, 2024 · 1. In this randomized controlled trial of men aged 50 to 60, forgoing prostate biopsies in those with elevated PSA but negative MRI reduced the diagnosis of clinically …
Finerenone reduces heart failure events in patients with HFpEF
Nov 26, 2024 · 1. In this randomized controlled trial of patients with heart failure and mildly decreased or preserved ejection fraction, finerenone treatment was associated with lower …
Belzutifan versus Everolimus for Advanced Renal-Cell Carcinoma
Sep 9, 2024 · In-Depth [randomized controlled trial]: This phase 3, multicenter, open-label trial enrolled adults with stage IV clear-cell renal-cell carcinoma who had disease progression after …
Invasive treatment not superior to medical therapy in older adults …
Dec 10, 2024 · 1. In this randomized controlled trial, in older adults with non-ST-segment elevation myocardial infarction (NSTEMI), invasive treatment did not significantly reduce the …